Anti-FADD antibody [7C4-F12-F1] (STJ99305)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant human FADD protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-FAS-associated death domain protein for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 7C4-F12-F1 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FADD |
| Gene ID | 8772 |
| Uniprot ID | FADD_HUMAN |
| Immunogen | Purified recombinant human FADD protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of FADD and does not cross-react with related proteins. |
Additional Info
| Post Translational Modifications | (Microbial infection) Glycosylated at Arg-117 by enteropathogenic E.coli protein NleB1, C.rodentium protein NleB and S.typhimurium protein Ssek1: arginine GlcNAcylation prevents recruitment of caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. |
| Function | Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. |
| Protein Name | Fas-Associated Death Domain ProteinFas-Associating Death Domain-Containing ProteinGrowth-Inhibiting Gene 3 ProteinMediator Of Receptor Induced Toxicity |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-2562578Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5675482Reactome: R-HSA-69416Reactome: R-HSA-75157Reactome: R-HSA-75158Reactome: R-HSA-9013957Reactome: R-HSA-933543Reactome: R-HSA-9693928 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Fas-Associated Death Domain Protein antibodyAnti-Fas-Associating Death Domain-Containing Protein antibodyAnti-Growth-Inhibiting Gene 3 Protein antibodyAnti-Mediator Of Receptor Induced Toxicity antibodyAnti-FADD antibodyAnti-MORT1 antibodyAnti-GIG3 antibody |
Information sourced from Uniprot.org