| Background | Factor XIIIa (FXIIIa) , also known as activated Factor XIII, is a blood coagulation factor that stabilizes fibrin and is present in monocytes, macrophages, platelets, megakaryocytes, dermal dendritic cells, and fibroblast-like mesenchymal or histiocytic cells in the placenta. Anti-Factor XIIIa is useful for distinguishing between dermatofibrosarcoma protuberans (±) , dermatofibroma (mostly +) , and desmoplastic malignant melanoma (-). Hemangioendothelioma, hemangiopericytoma, capillary hemagioblastoma, hepatocellular carcinoma, glomus tumour, xanthogranuloma, xanthoma, and meningioma all stain positively with Anti-Factor XIIIa. |
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