Anti-FA2H antibody (101-150 aa) (STJ99320)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human FA2H at the amino acid range 101-150
General Information
| Short Description | Rabbit polyclonal anti-Fatty acid 2-hydroxylase (101-150 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:10000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FA2H |
| Gene ID | 79152 |
| Uniprot ID | FA2H_HUMAN |
| Immunogen | Synthesized peptide derived from the human FA2H at the amino acid range 101-150 |
| Immunogen Region | 101-150 aa |
| Specificity | FA2H Polyclonal Antibody detects endogenous levels of FA2H |
Additional Info
| Function | Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins. |
| Protein Name | Fatty Acid 2-HydroxylaseFatty Acid Alpha-HydroxylaseFatty Acid Hydroxylase Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Fatty Acid 2-Hydroxylase antibodyAnti-Fatty Acid Alpha-Hydroxylase antibodyAnti-Fatty Acid Hydroxylase Domain-Containing Protein 1 antibodyAnti-FA2H antibodyAnti-FAAH antibodyAnti-FAXDC1 antibody |
Information sourced from Uniprot.org