| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-F11R (28-238) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
F11R |
| Gene ID: |
50848 |
| Uniprot ID: |
JAM1_HUMAN |
| Immunogen Region: |
28-238 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 28-238 of human JAM-A/CD321/F11R (NP_058642.1). |
| Immunogen Sequence: |
SVTVHSSEPEVRIPENNPVK LSCAYSGFSSPRVEWKFDQG DTTRLVCYNNKITASYEDRV TFLPTGITFKSVTREDTGTY TCMVSEEGGNSYGEVKVKLI VLVPPSKPTVNIPSSATIGN RAVLTCSEQDGSPPSEYTWF KDGIVMPTNPKSTRAFSNSS YVLNPTTGELVFDPLSASDT GEYSCEARNGYGTPMTSNAV RMEAVERNVGV |
| Tissue Specificity | Expressed in endothelium, epithelium and leukocytes (at protein level). |
| Post Translational Modifications | N-glycosylated. (Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions. |
| Function | Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. |
| Protein Name | Junctional Adhesion Molecule AJam-AJunctional Adhesion Molecule 1Jam-1Platelet F11 ReceptorPlatelet Adhesion Molecule 1Pam-1Cd Antigen Cd321 |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-2173791Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneSingle-Pass Type I Membrane ProteinLocalized At Tight Junctions Of Both Epithelial And Endothelial Cells |
| Alternative Antibody Names | Anti-Junctional Adhesion Molecule A antibodyAnti-Jam-A antibodyAnti-Junctional Adhesion Molecule 1 antibodyAnti-Jam-1 antibodyAnti-Platelet F11 Receptor antibodyAnti-Platelet Adhesion Molecule 1 antibodyAnti-Pam-1 antibodyAnti-Cd Antigen Cd321 antibodyAnti-F11R antibodyAnti-JAM1 antibodyAnti-JCAM antibodyAnti-UNQ264 antibodyAnti-PRO301 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
