| Host: | Rabbit |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-EZHIP for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | SQab30354 |
| Conjugation: | Unconjugated |
| Formulation: | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Purification: | Purification with Protein A. |
| Storage Instruction: | Store at-20°C for up to 1 year. Minimise freeze-thaw cycles. |
| Gene Symbol: | EZHIP |
| Gene ID: | 340602 |
| Uniprot ID: | EZHIP_HUMAN |
| Immunogen: | Synthetic peptide of EZHIP. |
| Function | Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2. Inhibits H3K27me3 deposition during spermatogenesis and oogenesis. |
| Protein Name | Ezh Inhibitory Protein |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Ezh Inhibitory Protein antibodyAnti-EZHIP antibodyAnti-CXorf67 antibody |
Information sourced from Uniprot.org
