Anti-EYA2 antibody (157-207) (STJA0006473)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human EYA2 AA range: 157-207
General Information
| Short Description | Rabbit polyclonal anti-Eyes absent homolog 2 (157-207) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EYA2 |
| Gene ID | 2139 |
| Uniprot ID | EYA2_HUMAN |
| Immunogen | Synthesized peptide derived from human EYA2 AA range: 157-207 |
| Immunogen Region | 157-207 |
| Specificity | This antibody detects endogenous levels of human EYA2 |
Additional Info
| Function | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2.in this it is functionally redundant with EYA1. |
| Protein Name | Protein Phosphatase Eya2Eyes Absent Homolog 2 |
| Database Links | Reactome: R-HSA-5693565 |
| Cellular Localisation | CytoplasmNucleusRetained In The Cytoplasm Via Interaction With Gnaz And Gnai2Interaction With Six1Six2Six4 Or Six5 Is Required For Translocation To The Nucleus |
| Alternative Antibody Names | Anti-Protein Phosphatase Eya2 antibodyAnti-Eyes Absent Homolog 2 antibodyAnti-EYA2 antibodyAnti-EAB1 antibody |
Information sourced from Uniprot.org