Anti-ETV4 antibody (50-109 aa) [1A2G3] (STJ98316)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human PEA3 (aa50-109) expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-ETS translocation variant 4 (50-109 aa) for use in WB and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1A2G3 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ETV4 |
| Gene ID | 2118 |
| Uniprot ID | ETV4_HUMAN |
| Immunogen | Purified recombinant fragment of human PEA3 (aa50-109) expressed in E. Coli. |
| Immunogen Region | 50-109 aa |
| Specificity | PEA3 Monoclonal Antibody detects endogenous levels of PEA3 protein. |
Additional Info
| Post Translational Modifications | Sumoylated.enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2. |
| Function | Transcriptional activator. May play a role in keratinocyte differentiation. (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator.the core-binding sequence is 5'-ACGGAATGT-3'. |
| Protein Name | Ets Translocation Variant 4Adenovirus E1a Enhancer-Binding ProteinE1a-FPolyomavirus Enhancer Activator 3 HomologProtein Pea3 |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ets Translocation Variant 4 antibodyAnti-Adenovirus E1a Enhancer-Binding Protein antibodyAnti-E1a-F antibodyAnti-Polyomavirus Enhancer Activator 3 Homolog antibodyAnti-Protein Pea3 antibodyAnti-ETV4 antibodyAnti-E1AF antibodyAnti-PEA3 antibody |
Information sourced from Uniprot.org