| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Extended synaptotagmin-1 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ESYT1 |
| Gene ID: | 23344 |
| Uniprot ID: | ESYT1_HUMAN |
| Specificity: | ESYT1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro).this promotes interaction with SLC2A4. |
| Function | Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. |
| Protein Name | Extended Synaptotagmin-1E-Syt1Membrane-Bound C2 Domain-Containing Protein |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9035034Reactome: R-HSA-9845576 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell MembranePeripheral Membrane ProteinLocalizes Primarily To The Endoplasmic ReticulumRecruited To Sites Of Contact Between The Endoplasmic Reticulum And The Cell Membrane In Response To Increased Cytosolic Calcium Levels |
| Alternative Antibody Names | Anti-Extended Synaptotagmin-1 antibodyAnti-E-Syt1 antibodyAnti-Membrane-Bound C2 Domain-Containing Protein antibodyAnti-ESYT1 antibodyAnti-FAM62A antibodyAnti-KIAA0747 antibodyAnti-MBC2 antibody |
Information sourced from Uniprot.org
