| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ESRRG |
| Gene ID: | 2104 |
| Uniprot ID: | ERR3_HUMAN |
| Immunogen Region: | 150-250 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human ESRRG (NP_001429.2). |
| Immunogen Sequence: | AFFKRTIQGNIEYSCPATNE CEITKRRRKSCQACRFMKCL KVGMLKEGVRLDRVRGGRQK YKRRIDAENSPYLNPQLVQP AKKPYNKIVSHLLVAEPEKI Y |
| Tissue Specificity | Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland. |
| Post Translational Modifications | Acetylated by PCAF/KAT2 (in vitro). Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity. Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity. |
| Function | Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle. |
| Protein Name | Estrogen-Related Receptor Gamma Err Gamma-2 Estrogen Receptor-Related Protein 3 Nuclear Receptor Subfamily 3 Group B Member 3 |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Estrogen-Related Receptor Gamma antibody Anti-Err Gamma-2 antibody Anti-Estrogen Receptor-Related Protein 3 antibody Anti-Nuclear Receptor Subfamily 3 Group B Member 3 antibody Anti-ESRRG antibody Anti-ERR3 antibody Anti-ERRG2 antibody Anti-KIAA0832 antibody Anti-NR3B3 antibody |
Information sourced from Uniprot.org