| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ESRP1 |
| Gene ID: | 54845 |
| Uniprot ID: | ESRP1_HUMAN |
| Immunogen Region: | 1-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ESRP1 (NP_060167.2). |
| Immunogen Sequence: | MTASPDYLVVLFGITAGATG AKLGSDEKELILLFWKVVDL ANKKVGQLHEVLVRPDQLEL TEDCKEETKIDVESLSSASQ LDQALRQFNQSVSNELNIGV GTSFCLCTDGQLHVRQILHP EASKKNVLLPECFYSFFDLR KEFKKCCPGSPDIDKLDVAT MTEYLNFEKSSSVSRYGASQ VEDMGNIILAMISEPYNHRF SDPERVNYKFESGTCSKMEL |
| Tissue Specificity | Epithelial cell-specific. |
| Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium. |
| Protein Name | Epithelial Splicing Regulatory Protein 1 Rna-Binding Motif Protein 35a Rna-Binding Protein 35a |
| Database Links | Reactome: R-HSA-6802952 Reactome: R-HSA-6803529 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Epithelial Splicing Regulatory Protein 1 antibody Anti-Rna-Binding Motif Protein 35a antibody Anti-Rna-Binding Protein 35a antibody Anti-ESRP1 antibody Anti-RBM35A antibody |
Information sourced from Uniprot.org