| Short Description : | Rabbit polyclonal ESRP1 (1-220) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ESRP1 |
| Gene ID: | 54845 |
| Uniprot ID: | ESRP1_HUMAN |
| Immunogen Region: | 1-220 |
| Immunogen Sequence: | MTASPDYLVVLFGITAGATG AKLGSDEKELILLFWKVVDL ANKKVGQLHEVLVRPDQLEL TEDCKEETKIDVESLSSASQ LDQALRQFNQSVSNELNIGV GTSFCLCTDGQLHVRQILHP EASKKNVLLPECFYSFFDLR KEFKKCCPGSPDIDKLDVAT MTEYLNFEKSSSVSRYGASQ VEDMGNIILAMISEPYNHRF SDPERVNYKFESGTCSKMEL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ESRP1 (NP_060167.2). |
| Tissue Specificity | Epithelial cell-specific. |
| Function | mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium. |
| Protein Name | Epithelial Splicing Regulatory Protein 1Rna-Binding Motif Protein 35aRna-Binding Protein 35a |
| Database Links | Reactome: R-HSA-6802952Reactome: R-HSA-6803529 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Epithelial Splicing Regulatory Protein 1 antibodyAnti-Rna-Binding Motif Protein 35a antibodyAnti-Rna-Binding Protein 35a antibodyAnti-ESRP1 antibodyAnti-RBM35A antibody |
Information sourced from Uniprot.org
