Anti-ERN2 antibody (841-890 aa) (STJ93759)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ERN2 at the amino acid range 841-890
General Information
| Short Description | Rabbit polyclonal anti-Serine/threonine-protein kinase/endoribonuclease IRE2 (841-890 aa) for use in IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ERN2 |
| Gene ID | 10595 |
| Uniprot ID | ERN2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ERN2 at the amino acid range 841-890 |
| Immunogen Region | 841-890 aa |
| Specificity | IRE1 Alpha/Beta Polyclonal Antibody detects endogenous levels of IRE1 Alpha/Beta protein. |
Additional Info
| Function | Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. |
| Protein Name | Serine/Threonine-Protein Kinase/Endoribonuclease Ire2Endoplasmic Reticulum-To-Nucleus Signaling 2Inositol-Requiring Protein 2Hire2pIre1-BetaIre1b Includes - Serine/Threonine-Protein Kinase - Endoribonuclease |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase/Endoribonuclease Ire2 antibodyAnti-Endoplasmic Reticulum-To-Nucleus Signaling 2 antibodyAnti-Inositol-Requiring Protein 2 antibodyAnti-Hire2p antibodyAnti-Ire1-Beta antibodyAnti-Ire1b Includes - Serine/Threonine-Protein Kinase - Endoribonuclease antibodyAnti-ERN2 antibodyAnti-IRE2 antibody |
Information sourced from Uniprot.org