Anti-Erlin-2 antibody (50-150) [S1MR] (STJ11102711)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Erlin-2 (50-150) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ERLIN2 |
| Gene ID | 11160 |
| Uniprot ID | ERLN2_HUMAN |
| Immunogen Region | 50-150 |
| Immunogen Sequence | HLMLPFITSYKSVQTTLQTD EVKNVPCGTSGGVMIYFDRI EVVNFLVPNAVYDIVKNYTA DYDKALIFNKIHHELNQFCS VHTLQEVYIELFDQIDENLK L |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Erlin-2 (O94905). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Deubiquitinated by USP25.leading to stabilization. |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex. |
| Protein Name | Erlin-2Endoplasmic Reticulum Lipid Raft-Associated Protein 2Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2Spfh Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-5655302Reactome: R-HSA-5678895Reactome: R-HSA-8853336 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinAssociated With Lipid Raft-Like Domains Of The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Erlin-2 antibodyAnti-Endoplasmic Reticulum Lipid Raft-Associated Protein 2 antibodyAnti-Stomatin-Prohibitin-Flotillin-Hflc/K Domain-Containing Protein 2 antibodyAnti-Spfh Domain-Containing Protein 2 antibodyAnti-ERLIN2 antibodyAnti-C8orf2 antibodyAnti-SPFH2 antibodyAnti-UNQ2441 antibodyAnti-PRO5003 antibodyAnti-PRO9924 antibody |
Information sourced from Uniprot.org