Anti-ERK5 antibody [4G5] (STJ196678)

SKU:
STJ196678

£168.00 - £226.00
Current Stock:
Host: Mouse
Applications: IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Mitogen-activated protein kinase 7 is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: 4G5
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MAPK7
Gene ID: 5598
Uniprot ID: MK07_HUMAN
Specificity: This antibody detects endogenous levels of ERK5 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the human ERK5
Post Translational Modifications Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme. Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
Function Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
Protein Name Mitogen-Activated Protein Kinase 7
Map Kinase 7
Mapk 7
Big Map Kinase 1
Bmk-1
Extracellular Signal-Regulated Kinase 5
Erk-5
Database Links Reactome: R-HSA-198753
Reactome: R-HSA-198765
Reactome: R-HSA-202670
Reactome: R-HSA-2559582
Reactome: R-HSA-881907
Reactome: R-HSA-8853659
Cellular Localisation Cytoplasm
Nucleus
Pml Body
Translocates To The Nucleus Upon Activation
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase 7 antibody
Anti-Map Kinase 7 antibody
Anti-Mapk 7 antibody
Anti-Big Map Kinase 1 antibody
Anti-Bmk-1 antibody
Anti-Extracellular Signal-Regulated Kinase 5 antibody
Anti-Erk-5 antibody
Anti-MAPK7 antibody
Anti-BMK1 antibody
Anti-ERK5 antibody
Anti-PRKM7 antibody

Information sourced from Uniprot.org

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