| Function | Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (TC-NER), a process during which RNA polymerase II-blocking lesions are rapidly removed from the transcribed strand of active genes. Following recruitment to lesion-stalled RNA polymerase II (Pol II), the CSA complex mediates ubiquitination of Pol II subunit POLR2A/RPB1 at 'Lys-1268', a critical TC-NER checkpoint, governing RNA Pol II stability and initiating DNA damage excision by TFIIH recruitment. The CSA complex also promotes the ubiquitination and subsequent proteasomal degradation of ERCC6/CSB in a UV-dependent manner.ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. Also plays a role in DNA double-strand breaks (DSSBs) repair by non-homologous end joining (NHEJ). |
| Protein Name | Dna Excision Repair Protein Ercc-8Cockayne Syndrome Wd Repeat Protein Csa |
| Database Links | Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusChromosomeNucleus MatrixRecruited To Lesion-Stalled Rna Polymerase Ii (Pol Ii) Sites By Ercc6/CsbUv-Induced Translocation To The Nuclear Matrix Is Dependent On Ercc6/Csb |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-8 antibodyAnti-Cockayne Syndrome Wd Repeat Protein Csa antibodyAnti-ERCC8 antibodyAnti-CKN1 antibodyAnti-CSA antibody |
Information sourced from Uniprot.org
