| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ERCC8 (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ERCC8 |
| Gene ID: |
1161 |
| Uniprot ID: |
ERCC8_HUMAN |
| Immunogen Region: |
C-Term |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human ERCC8 (NP_000073.1). |
| Immunogen Sequence: |
SCGCSSEFVFVPYGSTIAVY TVYSGEQITMLKGHYKTVDC CVFQSNFQELYSGSRDCNIL AWVPSLYEPVPDDDETTTKS QLNPAFEDAWSSSDEEG |
| Function | Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner.ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair.involved in repair of DSSBs by non-homologous end joining (NHEJ). |
| Protein Name | Dna Excision Repair Protein Ercc-8Cockayne Syndrome Wd Repeat Protein Csa |
| Database Links | Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusNucleus MatrixUv-Induced Translocation To The Nuclear Matrix Is Dependent On Ercc6 |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-8 antibodyAnti-Cockayne Syndrome Wd Repeat Protein Csa antibodyAnti-ERCC8 antibodyAnti-CKN1 antibodyAnti-CSA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
