| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERCC8 |
| Gene ID: | 1161 |
| Uniprot ID: | ERCC8_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human ERCC8 (NP_000073.1). |
| Immunogen Sequence: | SCGCSSEFVFVPYGSTIAVY TVYSGEQITMLKGHYKTVDC CVFQSNFQELYSGSRDCNIL AWVPSLYEPVPDDDETTTKS QLNPAFEDAWSSSDEEG |
| Function | Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner.ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair.involved in repair of DSSBs by non-homologous end joining (NHEJ). |
| Protein Name | Dna Excision Repair Protein Ercc-8Cockayne Syndrome Wd Repeat Protein Csa |
| Database Links | Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusNucleus MatrixUv-Induced Translocation To The Nuclear Matrix Is Dependent On Ercc6 |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-8 antibodyAnti-Cockayne Syndrome Wd Repeat Protein Csa antibodyAnti-ERCC8 antibodyAnti-CKN1 antibodyAnti-CSA antibody |
Information sourced from Uniprot.org
