Western blot analysis of various lysates using ERBB2IP Rabbit pAb (STJ111318) at 1:1000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Basic Kit <br/>Exposure time: 90s.

Anti-ERBB2IP antibody (1152-1371) (STJ111318)

⇓ Datasheet ⇓ SDS
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
STJ111318
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General Information

Short DescriptionRabbit polyclonal ERBB2IP (1152-1371) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
ApplicationsWB/ELISA
HostRabbit
ReactivityHuman
NoteSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

ClonalityPolyclonal
IsotypeIgG
ConjugationUnconjugated
ConcentrationLot specific
PurificationAffinity purification
Dilution RangeWB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
FormulationPBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage InstructionStore at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Target Information

Gene SymbolERBIN
Gene ID55914
Uniprot IDERBIN_HUMAN
Immunogen Region1152-1371
Immunogen SequenceIPERTMSVSDFNYSRTSPSK RPNARVGSEHSLLDPPGKSK VPRDWREQVLRHIEAKKLEK MPLSNGQMGQPLRPQANYSQ IHHPPQASVARHPSREQLID YLMLKVAHQPPYTQPHCSPR QGHELAKQEIRVRVEKDPEL GFSISGGVGGRGNPFRPDDD GIFVTRVQPEGPASKLLQPG DKIIQANGYSFINIEHGQAV SLLKTFQNTVELIIVREVSS
SpecificityRecombinant fusion protein containing a sequence corresponding to amino acids 1152-1371 of human ERBB2IP (NP_061165.1).

Additional Info

Tissue Specificity Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
Function Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion.
Protein Name Erbin
Densin-180-Like Protein
Erbb2-Interacting Protein
Protein Lap2
Database Links Reactome: R-HSA-1227986
Reactome: R-HSA-8863795
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013408
Reactome: R-HSA-9013423
Reactome: R-HSA-9634285
Reactome: R-HSA-9652282
Reactome: R-HSA-9664565
Reactome: R-HSA-9665233
Reactome: R-HSA-9665244
Reactome: R-HSA-9665245
Reactome: R-HSA-9665246
Reactome: R-HSA-9665247
Reactome: R-HSA-9665249
Reactome: R-HSA-9665250
Reactome: R-HSA-9665251
Reactome: R-HSA-9665348
Reactome: R-HSA-9665686
Reactome: R-HSA-9665737
Cellular Localisation Cell Junction
Hemidesmosome
Nucleus Membrane
Basolateral Cell Membrane
Found In Hemidesmosomes
Which Are Cell-Substrate Adhesion Complexes In Stratified Epithelia
In Transfected Cells
Either Diffusely Distributed Over The Cytoplasm Or Concentrated At The Basolateral Membrane
Colocalizes With The Adrenergic Receptors
Adren1a And Adren1b
At The Nuclear Membrane Of Cardiac Myocytes
Alternative Antibody Names Anti-Erbin antibody
Anti-Densin-180-Like Protein antibody
Anti-Erbb2-Interacting Protein antibody
Anti-Protein Lap2 antibody
Anti-ERBIN antibody
Anti-ERBB2IP antibody
Anti-KIAA1225 antibody
Anti-LAP2 antibody

Information sourced from Uniprot.org

Citations

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