| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ERBB2IP (1152-1371) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERBIN |
| Gene ID: | 55914 |
| Uniprot ID: | ERBIN_HUMAN |
| Immunogen Region: | 1152-1371 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1152-1371 of human ERBB2IP (NP_061165.1). |
| Immunogen Sequence: | IPERTMSVSDFNYSRTSPSK RPNARVGSEHSLLDPPGKSK VPRDWREQVLRHIEAKKLEK MPLSNGQMGQPLRPQANYSQ IHHPPQASVARHPSREQLID YLMLKVAHQPPYTQPHCSPR QGHELAKQEIRVRVEKDPEL GFSISGGVGGRGNPFRPDDD GIFVTRVQPEGPASKLLQPG DKIIQANGYSFINIEHGQAV SLLKTFQNTVELIIVREVSS |
| Tissue Specificity | Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine. |
| Function | Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion. |
| Protein Name | ErbinDensin-180-Like ProteinErbb2-Interacting ProteinProtein Lap2 |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-8863795Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9634285Reactome: R-HSA-9652282Reactome: R-HSA-9664565Reactome: R-HSA-9665233Reactome: R-HSA-9665244Reactome: R-HSA-9665245Reactome: R-HSA-9665246Reactome: R-HSA-9665247Reactome: R-HSA-9665249Reactome: R-HSA-9665250Reactome: R-HSA-9665251Reactome: R-HSA-9665348Reactome: R-HSA-9665686Reactome: R-HSA-9665737 |
| Cellular Localisation | Cell JunctionHemidesmosomeNucleus MembraneBasolateral Cell MembraneFound In HemidesmosomesWhich Are Cell-Substrate Adhesion Complexes In Stratified EpitheliaIn Transfected CellsEither Diffusely Distributed Over The Cytoplasm Or Concentrated At The Basolateral MembraneColocalizes With The Adrenergic ReceptorsAdren1a And Adren1bAt The Nuclear Membrane Of Cardiac Myocytes |
| Alternative Antibody Names | Anti-Erbin antibodyAnti-Densin-180-Like Protein antibodyAnti-Erbb2-Interacting Protein antibodyAnti-Protein Lap2 antibodyAnti-ERBIN antibodyAnti-ERBB2IP antibodyAnti-KIAA1225 antibodyAnti-LAP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
