| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EPPIN (22-133) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EPPIN |
| Gene ID: |
100526773/57119 |
| Uniprot ID: |
EPPI_HUMAN |
| Immunogen Region: |
22-133 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-133 of human EPPIN (NP_065131.1). |
| Immunogen Sequence: |
PGLTDWLFPRRCPKIREECE FQERDVCTKDRQCQDNKKCC VFSCGKKCLDLKQDVCEMPK ETGPCLAYFLHWWYDKKDNT CSMFVYGGCQGNNNNFQSKA NCLNTCKNKRFP |
| Tissue Specificity | In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells. |
| Function | Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. |
| Protein Name | EppinCancer/Testis Antigen 71Ct71Epididymal Protease InhibitorProtease Inhibitor Wap7Serine Protease Inhibitor-Like With Kunitz And Wap Domains 1Wap Four-Disulfide Core Domain Protein 7 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | Isoform 1: SecretedCell SurfaceBound To The Surface Of Testicular And On The Head And Tail Of Ejaculate Spermatozoa |
| Alternative Antibody Names | Anti-Eppin antibodyAnti-Cancer/Testis Antigen 71 antibodyAnti-Ct71 antibodyAnti-Epididymal Protease Inhibitor antibodyAnti-Protease Inhibitor Wap7 antibodyAnti-Serine Protease Inhibitor-Like With Kunitz And Wap Domains 1 antibodyAnti-Wap Four-Disulfide Core Domain Protein 7 antibodyAnti-EPPIN antibodyAnti-SPINLW1 antibodyAnti-WAP7 antibodyAnti-WFDC7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
