| Post Translational Modifications | Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion. |
| Function | Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. |
| Protein Name | Ephrin Type-B Receptor 6HepTyrosine-Protein Kinase-Defective Receptor Eph-6 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928662Reactome: R-HSA-3928664Reactome: R-HSA-3928665 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinIsoform 3: Secreted |
| Alternative Nanobody Names | Anti-Ephrin Type-B Receptor 6 nanobodyAnti-Hep nanobodyAnti-Tyrosine-Protein Kinase-Defective Receptor Eph-6 nanobodyAnti-EPHB6 nanobody |
Information sourced from Uniprot.org
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