Host: | Rabbit |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Ephrin type-B receptor 6 (861-910 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | EPHB6 |
Gene ID: | 2051 |
Uniprot ID: | EPHB6_HUMAN |
Immunogen Region: | 861-910 aa |
Specificity: | EphB6 Polyclonal Antibody detects endogenous levels of EphB6 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human EPHB6 at the amino acid range 861-910 |
Post Translational Modifications | Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion. |
Function | Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. |
Protein Name | Ephrin Type-B Receptor 6 Hep Tyrosine-Protein Kinase-Defective Receptor Eph-6 |
Database Links | Reactome: R-HSA-2682334 Reactome: R-HSA-3928662 Reactome: R-HSA-3928664 Reactome: R-HSA-3928665 |
Cellular Localisation | Membrane Single-Pass Type I Membrane Protein Isoform 3: Secreted |
Alternative Antibody Names | Anti-Ephrin Type-B Receptor 6 antibody Anti-Hep antibody Anti-Tyrosine-Protein Kinase-Defective Receptor Eph-6 antibody Anti-EPHB6 antibody |
Information sourced from Uniprot.org