Anti-EPHA8 antibody {FITC} (STJ500929)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic peptide corresponding to unique amino acid sequences on human EphA R8 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-EPHA8 is suitable for use in ELISA and Western Blot research applications. |
| Applications | ELISA/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.55-0.75 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | EPHA8 |
| Gene ID | 2046 |
| Uniprot ID | EPHA8_HUMAN |
| Immunogen | Synthetic peptide corresponding to unique amino acid sequences on human EphA R8 protein. |
Additional Info
| Function | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth. |
| Protein Name | Ephrin Type-A Receptor 8Eph- And Elk-Related KinaseEph-Like Kinase 3Ek3Hek3Tyrosine-Protein Kinase Receptor Eek |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928663Reactome: R-HSA-3928665 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionEarly Endosome MembraneUndergoes Clathrin-Mediated Endocytosis Upon Efna5-Binding And Is Targeted To Early Endosomes |
| Alternative Antibody Names | Anti-Ephrin Type-A Receptor 8 antibodyAnti-Eph- And Elk-Related Kinase antibodyAnti-Eph-Like Kinase 3 antibodyAnti-Ek3 antibodyAnti-Hek3 antibodyAnti-Tyrosine-Protein Kinase Receptor Eek antibodyAnti-EPHA8 antibodyAnti-EEK antibodyAnti-HEK3 antibodyAnti-KIAA1459 antibody |
Information sourced from Uniprot.org