| Tissue Specificity | Highly expressed in skeletal muscle. Expressed in liver, lung, placenta, brain, heart, kidney and ovarian tissues. Expressed in testis at the blood-brain-barrier. |
| Post Translational Modifications | Glycosylated. |
| Function | Bidirectional uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent, passive transporter. Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine. Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites. Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier. Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production. Isoform 3: Non functional nucleoside transporter protein for adenosine or thymidine transport. Does not express on cell membrane. |
| Protein Name | Equilibrative Nucleoside Transporter 2Hent236 Kda Nucleolar Protein Hnp36Delayed-Early Response Protein 12Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside TransporterEquilibrative Nbmpr-Insensitive Nucleoside TransporterHydrophobic Nucleolar Protein - 36 KdaNucleoside Transporter - Ei-TypeSolute Carrier Family 29 Member 2 |
| Database Links | Reactome: R-HSA-83936Reactome: R-HSA-9748787 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneLocalized To The Apical Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Equilibrative Nucleoside Transporter 2 antibodyAnti-Hent2 antibodyAnti-36 Kda Nucleolar Protein Hnp36 antibodyAnti-Delayed-Early Response Protein 12 antibodyAnti-Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside Transporter antibodyAnti-Equilibrative Nbmpr-Insensitive Nucleoside Transporter antibodyAnti-Hydrophobic Nucleolar Protein - 36 Kda antibodyAnti-Nucleoside Transporter - Ei-Type antibodyAnti-Solute Carrier Family 29 Member 2 antibodyAnti-SLC29A2 antibodyAnti-DER12 antibodyAnti-ENT2 antibodyAnti-HNP36 antibody |
Information sourced from Uniprot.org
