| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ENPP4 |
| Gene ID: | 22875 |
| Uniprot ID: | ENPP4_HUMAN |
| Immunogen Region: | 90-230 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-230 of human ENPP4 (NP_055751.1). |
| Immunogen Sequence: | ANSMYDAVTKKHFSDSNDKD PFWWNEAVPIWVTNQLQENR SSAAAMWPGTDVPIHDTISS YFMNYNSSVSFEERLNNITM WLNNSNPPVTFATLYWEEPD ASGHKYGPEDKENMSRVLKK IDDLIGDLVQRLKMLGLWEN L |
| Tissue Specificity | Expressed on the surface of vascular endothelia. |
| Function | Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. |
| Protein Name | Bis(5'-Adenosyl-Triphosphatase Enpp4Ap3a HydrolaseAp3aaseEctonucleotide Pyrophosphatase/Phosphodiesterase Family Member 4E-Npp 4Npp-4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Bis(5'-Adenosyl-Triphosphatase Enpp4 antibodyAnti-Ap3a Hydrolase antibodyAnti-Ap3aase antibodyAnti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 4 antibodyAnti-E-Npp 4 antibodyAnti-Npp-4 antibodyAnti-ENPP4 antibodyAnti-KIAA0879 antibodyAnti-NPP4 antibody |
Information sourced from Uniprot.org