| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ENPP3 (646-875) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ENPP3 |
| Gene ID: |
5169 |
| Uniprot ID: |
ENPP3_HUMAN |
| Immunogen Region: |
646-875 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 646-875 of human ENPP3 (NP_005012.2). |
| Immunogen Sequence: |
YTVPQLGDTSPLPPTVPDCL RADVRVPPSESQKCSFYLAD KNITHGFLYPPASNRTSDSQ YDALITSNLVPMYEEFRKMW DYFHSVLLIKHATERNGVNV VSGPIFDYNYDGHFDAPDEI TKHLANTDVPIPTHYFVVLT SCKNKSHTPENCPGWLDVLP FIIPHRPTNVESCPEGKPEA LWVEERFTAHIARVRDVELL TGLDFYQDKVQPVSEILQLK TYLPTFETTI |
| Tissue Specificity | Detected on bile ducts in liver, and in blood serum (at protein level). Detected in prostate and uterus. Detected on basophils, but not neutrophils. |
| Post Translational Modifications | N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal. |
| Function | Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity. |
| Protein Name | Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3E-Npp 3Npp3Phosphodiesterase I BetaPd-IbetaPhosphodiesterase I/Nucleotide Pyrophosphatase 3Cd Antigen Cd203c Includes - Alkaline Phosphodiesterase I - Nucleotide PyrophosphataseNppaseNucleotide Diphosphatase |
| Database Links | Reactome: R-HSA-199220 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell MembraneSecretedDetected At The Cell Surface Of BasophilsDetected At The Apical Plasma Membrane Of Bile Duct CellsLocated To The Apical Surface In Intestinal And Kidney Epithelial CellsSecreted In SerumAnd In Lumen Of Epithelial Cells |
| Alternative Antibody Names | Anti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 antibodyAnti-E-Npp 3 antibodyAnti-Npp3 antibodyAnti-Phosphodiesterase I Beta antibodyAnti-Pd-Ibeta antibodyAnti-Phosphodiesterase I/Nucleotide Pyrophosphatase 3 antibodyAnti-Cd Antigen Cd203c Includes - Alkaline Phosphodiesterase I - Nucleotide Pyrophosphatase antibodyAnti-Nppase antibodyAnti-Nucleotide Diphosphatase antibodyAnti-ENPP3 antibodyAnti-PDNP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
