Anti-Endophilin-A1/SH3GL2, Biotinylated antibody (Internal) {Biotin} (STJ73515)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationBiotin
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Endophilin-A1/SH3GL2, Biotinylated (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 38kDa band observed in Human Brain (Frontal Cortex) lysates (calculated MW of 40.0kDa according to NP_003017.1). Recommended concentration: 0.3-1ยตg/ml. See non-biotinylated pare |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SH3GL2 |
| Gene ID | 6456 |
| Uniprot ID | SH3G2_HUMAN |
| Accession Number | NP_003017.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | CSLEFPTGDSTQPN. |
Additional Info
| Function | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. |
| Protein Name | Endophilin-A1Een-B1Endophilin-1Sh3 Domain Protein 2aSh3 Domain-Containing Grb2-Like Protein 2 |
| Database Links | Reactome: R-HSA-177504Reactome: R-HSA-182971Reactome: R-HSA-2132295Reactome: R-HSA-432720Reactome: R-HSA-432722Reactome: R-HSA-437239Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinEarly EndosomePresynapse |
| Alternative Antibody Names | Anti-Endophilin-A1 antibodyAnti-Een-B1 antibodyAnti-Endophilin-1 antibodyAnti-Sh3 Domain Protein 2a antibodyAnti-Sh3 Domain-Containing Grb2-Like Protein 2 antibodyAnti-SH3GL2 antibodyAnti-CNSA2 antibodyAnti-SH3D2A antibody |
Information sourced from Uniprot.org