| Function | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). |
| Protein Name | Er Membrane Protein Complex Subunit 2Tetratricopeptide Repeat Protein 35Tpr Repeat Protein 35 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideMay Also Localize To The Nuclear Envelope |
| Alternative Antibody Names | Anti-Er Membrane Protein Complex Subunit 2 antibodyAnti-Tetratricopeptide Repeat Protein 35 antibodyAnti-Tpr Repeat Protein 35 antibodyAnti-EMC2 antibodyAnti-KIAA0103 antibodyAnti-TTC35 antibody |
Information sourced from Uniprot.org
