| Tissue Specificity | Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates. |
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. |
| Protein Name | Very Long Chain Fatty Acid Elongase 43-Keto Acyl-Coa Synthase Elovl4Elovl Fatty Acid Elongase 4Elovl Fa Elongase 4Elongation Of Very Long Chain Fatty Acids Protein 4Very Long Chain 3-Ketoacyl-Coa Synthase 4Very Long Chain 3-Oxoacyl-Coa Synthase 4 |
| Database Links | Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Very Long Chain Fatty Acid Elongase 4 antibodyAnti-3-Keto Acyl-Coa Synthase Elovl4 antibodyAnti-Elovl Fatty Acid Elongase 4 antibodyAnti-Elovl Fa Elongase 4 antibodyAnti-Elongation Of Very Long Chain Fatty Acids Protein 4 antibodyAnti-Very Long Chain 3-Ketoacyl-Coa Synthase 4 antibodyAnti-Very Long Chain 3-Oxoacyl-Coa Synthase 4 antibodyAnti-ELOVL4 antibody |
Information sourced from Uniprot.org
