| Short Description : | Goat polyclonal antibody anti-ELMO2 (C-Term) is suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunofluorescence and Flow Cytometry research applications. |
| Applications: | Pep-ELISA/WB/IHC/IF/FC |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 80kDa band observed in lysates of cell lines HEK293, Jurkat, RAW264.7 and in Human Cerebellum and Rat Brain lysates (calculated MW of 82.6kDa according to Human NP_573403.1 and |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ELMO2 |
| Gene ID: | 63916 |
| Uniprot ID: | ELMO2_HUMAN |
| Accession Number: | NP_877496.1; NP_573403.1 |
| Immunogen Region: | C-Term |
| Immunogen Sequence: | PKEPSSYDFVYHYG |
| Specificity: | NP_877496.1 and NP_573403.1 are varients that encode the same protein. |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Protein Name | Engulfment And Cell Motility Protein 2Protein Ced-12 Homolog AHced-12a |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9013408Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCytosolMembrane |
| Alternative Antibody Names | Anti-Engulfment And Cell Motility Protein 2 antibodyAnti-Protein Ced-12 Homolog A antibodyAnti-Hced-12a antibodyAnti-ELMO2 antibodyAnti-CED12A antibodyAnti-KIAA1834 antibody |
Information sourced from Uniprot.org
