| Tissue Specificity | Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. |
| Function | Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGAAT. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters. |
| Protein Name | Ets-Related Transcription Factor Elf-5E74-Like Factor 5Epithelium-Restricted Ese-1-Related Ets FactorEpithelium-Specific Ets Transcription Factor 2Ese-2 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ets-Related Transcription Factor Elf-5 antibodyAnti-E74-Like Factor 5 antibodyAnti-Epithelium-Restricted Ese-1-Related Ets Factor antibodyAnti-Epithelium-Specific Ets Transcription Factor 2 antibodyAnti-Ese-2 antibodyAnti-ELF5 antibodyAnti-ESE2 antibody |
Information sourced from Uniprot.org
