Anti-ELF4 antibody (178-227 aa) (STJ92889)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ELF4 at the amino acid range 178-227
General Information
| Short Description | Rabbit polyclonal anti-ETS-related transcription factor Elf-4 (178-227 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ELF4 |
| Gene ID | 2000 |
| Uniprot ID | ELF4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ELF4 at the amino acid range 178-227 |
| Immunogen Region | 178-227 aa |
| Specificity | Elf-4 Polyclonal Antibody detects endogenous levels of Elf-4 protein. |
Additional Info
| Function | Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter. Transactivates the PRF1 promoter in natural killer (NK) cells and CD8+ T cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN. Is a negative regulator of pro-inflammatory cytokines expression including IL17A, IL1B, IL6, TNFA and CXCL1. Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses. |
| Protein Name | Ets-Related Transcription Factor Elf-4E74-Like Factor 4Myeloid Elf-1-Like Factor |
| Database Links | |
| Cellular Localisation | NucleusPml BodyAccumulation Into Pml Nuclear Bodies Is Mediated By Pml |
| Alternative Antibody Names | Anti-Ets-Related Transcription Factor Elf-4 antibodyAnti-E74-Like Factor 4 antibodyAnti-Myeloid Elf-1-Like Factor antibodyAnti-ELF4 antibodyAnti-ELFR antibodyAnti-MEF antibody |
Information sourced from Uniprot.org