• Immunohistochemistry analysis of paraffin-embedded human pancreas carcinoma (A) , esophagus carcinoma tissue (B) and ovary tumor tissue, showing cytoplasmic and membrane localization with DAB staining using 4E-BP1 monoclonal antibody.
  • Western blot analysis using 4E-BP1 monoclonal antibody against truncated 4E-BP1 recombinant protein (1).

Anti-EIF4EBP1 antibody [11G12C11] (STJ97805)

SKU:
STJ97805

£139.00 - £336.00
Current Stock:
Host: Mouse
Applications: WB/IHC/IF/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Eukaryotic translation initiation factor 4E-binding protein 1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Monoclonal
Clone ID: 11G12C11
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide.
Purification: Affinity purification
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF4EBP1
Gene ID: 1978
Uniprot ID: 4EBP1_HUMAN
Specificity: 4E-BP1 Monoclonal Antibody detects endogenous levels of 4E-BP1 protein.
Immunogen: Purified recombinant fragment of 4E-BP1 expressed in E. Coli.
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Protein Name Eukaryotic Translation Initiation Factor 4e-Binding Protein 1
4e-Bp1
Eif4e-Binding Protein 1
Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1
Phas-I
Database Links Reactome: R-HSA-166208
Reactome: R-HSA-72662
Cellular Localisation Cytoplasm
Nucleus
Localization To The Nucleus Is Unaffected By Phosphorylation Status
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 4e-Binding Protein 1 antibody
Anti-4e-Bp1 antibody
Anti-Eif4e-Binding Protein 1 antibody
Anti-Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 antibody
Anti-Phas-I antibody
Anti-EIF4EBP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance