| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EIF2S3 |
| Gene ID: | 1968 |
| Uniprot ID: | IF2G_HUMAN |
| Immunogen Region: | 1-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human EIF2S3 (NP_001406.1). |
| Immunogen Sequence: | MAGGEAGVTLGQPHLSRQDL TTLDVTKLTPLSHEVISRQA TINIGTIGHVAHGKSTVVKA ISGVHTVRFKNELERNITIK LGYANAKIYKLDDPSCPRPE CYRSCGSSTPDEFPTDIPGT KGNFKLVRHVSFVDCPGHDI LMATMLNGAAVMDAALLLIA GNESCPQPQTSEHLAAIEIM KLKHILILQNKIDLVKESQA KEQYEQILAFVQGTVAEGAP IIPISAQLKYNIEVVCEYI |
| Tissue Specificity | Expressed in testis, brain, liver and muscle. |
| Function | Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
| Protein Name | Eukaryotic Translation Initiation Factor 2 Subunit 3 Eukaryotic Translation Initiation Factor 2 Subunit Gamma X Eif2-Gamma X Eif2gx |
| Database Links | Reactome: R-HSA-156827 Reactome: R-HSA-381042 Reactome: R-HSA-382556 Reactome: R-HSA-72649 Reactome: R-HSA-72695 Reactome: R-HSA-72702 Reactome: R-HSA-72706 Reactome: R-HSA-72731 Reactome: R-HSA-9633012 Reactome: R-HSA-9648895 Reactome: R-HSA-9833482 Reactome: R-HSA-9840373 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 2 Subunit 3 antibody Anti-Eukaryotic Translation Initiation Factor 2 Subunit Gamma X antibody Anti-Eif2-Gamma X antibody Anti-Eif2gx antibody Anti-EIF2S3 antibody Anti-EIF2G antibody |
Information sourced from Uniprot.org