Anti-EHMT1/GLP1 antibody (950-100) (STJ506053)

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STJ506053-100
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Short Description :Rabbit polyclonal antibody anti-EHMT1/GLP1 (950-100) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Applications:ELISA/IP/WB
Host:Rabbit
Reactivity:Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:0.5-1.5 µg/µl
Purification:Affinity Purified
Dilution Range:WB: 1:500
ELISA: 1:50, 000
IP: 1:200
Formulation:Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction:Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol:EHMT1
Gene ID:79813
Uniprot ID:EHMT1_HUMAN
Immunogen:Synthetic peptide taken within amino acid region 950-100 on human Histone-lysine N-methyltransferase EHMT1/GLP1.
Immunogen Region:950-100
Tissue Specificity Widely expressed.
Function Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B.
Protein Name Histone-Lysine N-Methyltransferase Ehmt1
Euchromatic Histone-Lysine N-Methyltransferase 1
Eu-Hmtase1
G9a-Like Protein 1
Glp
Glp1
Histone H3-K9 Methyltransferase 5
H3-K9-Hmtase 5
Lysine N-Methyltransferase 1d
Database Links Reactome: R-HSA-2559582
Reactome: R-HSA-3214841
Reactome: R-HSA-6804760
Reactome: R-HSA-8853884
Reactome: R-HSA-8953750
Reactome: R-HSA-9843970
Cellular Localisation Nucleus
Chromosome
Associates With Euchromatic Regions
Alternative Antibody Names Anti-Histone-Lysine N-Methyltransferase Ehmt1 antibody
Anti-Euchromatic Histone-Lysine N-Methyltransferase 1 antibody
Anti-Eu-Hmtase1 antibody
Anti-G9a-Like Protein 1 antibody
Anti-Glp antibody
Anti-Glp1 antibody
Anti-Histone H3-K9 Methyltransferase 5 antibody
Anti-H3-K9-Hmtase 5 antibody
Anti-Lysine N-Methyltransferase 1d antibody
Anti-EHMT1 antibody
Anti-EUHMTASE1 antibody
Anti-GLP antibody
Anti-KIAA1876 antibody
Anti-KMT1D antibody

Information sourced from Uniprot.org

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