| Host: |
Rabbit |
| Applications: |
ELISA/IP/WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EHMT1/GLP1 (950-100) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5-1.5 µg/µl |
| Dilution Range: |
WB: 1:500ELISA: 1:50, 000IP: 1:200 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
EHMT1 |
| Gene ID: |
79813 |
| Uniprot ID: |
EHMT1_HUMAN |
| Immunogen Region: |
950-100 |
| Immunogen: |
Synthetic peptide taken within amino acid region 950-100 on human Histone-lysine N-methyltransferase EHMT1/GLP1. |
| Tissue Specificity | Widely expressed. |
| Function | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B. |
| Protein Name | Histone-Lysine N-Methyltransferase Ehmt1Euchromatic Histone-Lysine N-Methyltransferase 1Eu-Hmtase1G9a-Like Protein 1GlpGlp1Histone H3-K9 Methyltransferase 5H3-K9-Hmtase 5Lysine N-Methyltransferase 1d |
| Database Links | Reactome: R-HSA-2559582Reactome: R-HSA-3214841Reactome: R-HSA-6804760Reactome: R-HSA-8853884Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusChromosomeAssociates With Euchromatic Regions |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Ehmt1 antibodyAnti-Euchromatic Histone-Lysine N-Methyltransferase 1 antibodyAnti-Eu-Hmtase1 antibodyAnti-G9a-Like Protein 1 antibodyAnti-Glp antibodyAnti-Glp1 antibodyAnti-Histone H3-K9 Methyltransferase 5 antibodyAnti-H3-K9-Hmtase 5 antibodyAnti-Lysine N-Methyltransferase 1d antibodyAnti-EHMT1 antibodyAnti-EUHMTASE1 antibodyAnti-GLP antibodyAnti-KIAA1876 antibodyAnti-KMT1D antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
