• Immunohistochemistry of mouse kidney with Anti-EHD3 primary antibody (STJ500855) at 1:50 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-EHD3 antibody (475-535) (STJ500855)

SKU:
STJ500855-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EHD3 (475-535) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.58 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: EHD3
Gene ID: 30845
Uniprot ID: EHD3_HUMAN
Immunogen Region: 475-535
Immunogen: Synthetic peptide taken within amino acid region 475-535 on human EH-domain containing protein 3.
Tissue Specificity Highly expressed in heart and brain and moderately expressed in kidney, liver, and placenta.
Function ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology. Involved in the recycling of internalized D1 dopamine receptor. Plays a role in cardiac protein trafficking probably implicating ANK2. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction. In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function. Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis.possibly sharing redundant functions with EHD1.
Protein Name Eh Domain-Containing Protein 3
Past Homolog 3
Database Links Reactome: R-HSA-983231
Cellular Localisation Recycling Endosome Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Membrane
Cell Projection
Cilium Membrane
Localizes To The Ciliary Pocket From Where The Cilium Protrudes
Colocalizes With Rab8a And Myo5b To A Cytoplasmic Tubular Network Devoid Of Rab11a
Colocalizes With Ank2 In Myocyte Perinuclear Region
Colocalizes With Bace1 In Tubulovesicular Cytoplasmic Membranes
Colocalizes With Bace1 And App Amyloid Beta Proteins In Hippocampal Mossy Fiber Terminals
Alternative Antibody Names Anti-Eh Domain-Containing Protein 3 antibody
Anti-Past Homolog 3 antibody
Anti-EHD3 antibody
Anti-EHD2 antibody
Anti-PAST3 antibody

Information sourced from Uniprot.org

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