| Host: |
Rabbit |
| Applications: |
ELISA/IHC/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-EHD3 (475-535) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.58 µg/µl |
| Dilution Range: |
WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:50-1:150 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
EHD3 |
| Gene ID: |
30845 |
| Uniprot ID: |
EHD3_HUMAN |
| Immunogen Region: |
475-535 |
| Immunogen: |
Synthetic peptide taken within amino acid region 475-535 on human EH-domain containing protein 3. |
| Tissue Specificity | Highly expressed in heart and brain and moderately expressed in kidney, liver, and placenta. |
| Function | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology. Involved in the recycling of internalized D1 dopamine receptor. Plays a role in cardiac protein trafficking probably implicating ANK2. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction. In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function. Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis.possibly sharing redundant functions with EHD1. |
| Protein Name | Eh Domain-Containing Protein 3Past Homolog 3 |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | Recycling Endosome MembranePeripheral Membrane ProteinCytoplasmic SideCell MembraneCell ProjectionCilium MembraneLocalizes To The Ciliary Pocket From Where The Cilium ProtrudesColocalizes With Rab8a And Myo5b To A Cytoplasmic Tubular Network Devoid Of Rab11aColocalizes With Ank2 In Myocyte Perinuclear RegionColocalizes With Bace1 In Tubulovesicular Cytoplasmic MembranesColocalizes With Bace1 And App Amyloid Beta Proteins In Hippocampal Mossy Fiber Terminals |
| Alternative Antibody Names | Anti-Eh Domain-Containing Protein 3 antibodyAnti-Past Homolog 3 antibodyAnti-EHD3 antibodyAnti-EHD2 antibodyAnti-PAST3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
