Anti-EFEMP2 antibody (91-140 aa) (STJ93074)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human EFEMP2 at the amino acid range 91-140
General Information
| Short Description | Rabbit polyclonal anti-EGF-containing fibulin-like extracellular matrix protein 2 (91-140 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EFEMP2 |
| Gene ID | 30008 |
| Uniprot ID | FBLN4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human EFEMP2 at the amino acid range 91-140 |
| Immunogen Region | 91-140 aa |
| Specificity | Fibulin-4 Polyclonal Antibody detects endogenous levels of Fibulin-4 protein. |
Additional Info
| Function | Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin. Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling. |
| Protein Name | Egf-Containing Fibulin-Like Extracellular Matrix Protein 2Fibulin-4Fibl-4Protein Uph1 |
| Database Links | Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneLocalizes On The Microfibrils Surrounding Eln Cores |
| Alternative Antibody Names | Anti-Egf-Containing Fibulin-Like Extracellular Matrix Protein 2 antibodyAnti-Fibulin-4 antibodyAnti-Fibl-4 antibodyAnti-Protein Uph1 antibodyAnti-EFEMP2 antibodyAnti-FBLN4 antibodyAnti-UNQ200 antibodyAnti-PRO226 antibody |
Information sourced from Uniprot.org