| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-EDNRB (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1: 1000 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | EDNRB |
| Gene ID: | 1910 |
| Uniprot ID: | EDNRB_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | Specific for EDNRB. |
| Immunogen: | A synthetic peptide from the c-terminal of human Endothelin B receptor conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Post Translational Modifications | Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405. |
| Function | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Name | Endothelin Receptor Type BEt-BEt-BrEndothelin Receptor Non-Selective Type |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalized After Activation By Endothelins |
| Alternative Antibody Names | Anti-Endothelin Receptor Type B antibodyAnti-Et-B antibodyAnti-Et-Br antibodyAnti-Endothelin Receptor Non-Selective Type antibodyAnti-EDNRB antibodyAnti-ETRB antibody |
Information sourced from Uniprot.org
