Anti-dysferlin antibody (Internal) (STJ73561)

SKU:
STJ73561-100

£188.50
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Host: Goat
Applications: Pep-ELISA
Reactivity: Human/Rat/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-dysferlin (Internal) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: DYSF
Gene ID: 8291
Uniprot ID: DYSF_HUMAN
Immunogen Region: Internal
Accession Number: NP_001124459.1; NP_001123927.1; NP_001124458.1; NP_001124457.1; NP_001124456.1; NP_001124455.1; NP_001124454.1; NP_003485.1; NP_001124448.1; NP_001124449.1; NP_001124450.1; NP_001124451.1; NP_001124452.1; NP_001124453.1
Specificity: This antibody is expected to recognize all 14 reported isoforms.
Immunogen Sequence: HLFCQQHRVKAP
Function Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
Protein Name Dysferlin
Dystrophy-Associated Fer-1-Like Protein
Fer-1-Like Protein 1
Database Links Reactome: R-HSA-445355
Cellular Localisation Cell Membrane
Sarcolemma
Single-Pass Type Ii Membrane Protein
Cytoplasmic Vesicle Membrane
Colocalizes
During Muscle Differentiation
With Bin1 In The T-Tubule System Of Myotubules And At The Site Of Contact Between Two Myotubes Or A Myoblast And A Myotube
Wounding Of Myotubes Led To Its Focal Enrichment To The Site Of Injury And To Its Relocalization In A Ca(2+)-Dependent Manner Toward The Plasma Membrane
Colocalizes With Ahnak
Ahnak2 And Parvb At The Sarcolemma Of Skeletal Muscle
Detected On The Apical Plasma Membrane Of The Syncytiotrophoblast
Reaches The Plasmma Membrane Through A Caveolin-Independent Mechanism
Retained By Caveolin At The Plasmma Membrane
With Cacna1s In The T-Tubule System Of Myotubules
Accumulates And Colocalizes With Fusion Vesicles At The Sarcolemma Disruption Sites
Alternative Antibody Names Anti-Dysferlin antibody
Anti-Dystrophy-Associated Fer-1-Like Protein antibody
Anti-Fer-1-Like Protein 1 antibody
Anti-DYSF antibody
Anti-FER1L1 antibody

Information sourced from Uniprot.org

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