• Anti-Dysferlin antibody [Ham3/17B2] (STJ16101746)

Anti-Dysferlin antibody [Ham3/17B2] (STJ16101746)

SKU:
STJ16101746-1

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Host: Mouse
Applications: IHC-P/IHC-F
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Dysferlin is suitable for use in Immunohistochemistry and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: Ham3/17B2
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: Lyophilized
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: DYSF
Gene ID: 8291
Uniprot ID: DYSF_HUMAN
Tissue Specificity Expressed in skeletal muscle, myoblast, myotube and in the syncytiotrophoblast (STB) of the placenta (at protein level). Ubiquitous. Highly expressed in skeletal muscle. Also found in heart, brain, spleen, intestine, placenta and at lower levels in liver, lung, kidney and pancreas.
Function Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
Protein Name Dysferlin
Dystrophy-Associated Fer-1-Like Protein
Fer-1-Like Protein 1
Database Links Reactome: R-HSA-445355
Cellular Localisation Cell Membrane
Sarcolemma
Single-Pass Type Ii Membrane Protein
Cytoplasmic Vesicle Membrane
Colocalizes
During Muscle Differentiation
With Bin1 In The T-Tubule System Of Myotubules And At The Site Of Contact Between Two Myotubes Or A Myoblast And A Myotube
Wounding Of Myotubes Led To Its Focal Enrichment To The Site Of Injury And To Its Relocalization In A Ca(2+)-Dependent Manner Toward The Plasma Membrane
Colocalizes With Ahnak
Ahnak2 And Parvb At The Sarcolemma Of Skeletal Muscle
Detected On The Apical Plasma Membrane Of The Syncytiotrophoblast
Reaches The Plasmma Membrane Through A Caveolin-Independent Mechanism
Retained By Caveolin At The Plasmma Membrane
With Cacna1s In The T-Tubule System Of Myotubules
Accumulates And Colocalizes With Fusion Vesicles At The Sarcolemma Disruption Sites
Alternative Antibody Names Anti-Dysferlin antibody
Anti-Dystrophy-Associated Fer-1-Like Protein antibody
Anti-Fer-1-Like Protein 1 antibody
Anti-DYSF antibody
Anti-FER1L1 antibody

Information sourced from Uniprot.org

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