Anti-DYRK1A antibody (624-763) (STJ110998)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DYRK1A (624-763) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DYRK1A |
| Gene ID | 1859 |
| Uniprot ID | DYR1A_HUMAN |
| Immunogen Region | 624-763 |
| Immunogen Sequence | LGNRTRPRVYNSPTNSSSTQ DSMEVGHSHHSMTSLSSSTT SSSTSSSSTGNQGNQAYQNR PVAANTLDFGQNGAMDVNLT VYSNPRQETGIAGHPTYQFS ANTGPAHYMTEGHLTMRQGA DREESPMTGVCVQQSPVASS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 624-763 of human DYRK1A (NP_001387.2). |
Additional Info
| Tissue Specificity | Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. |
| Post Translational Modifications | Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro). |
| Function | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits p53/TP53 activity and apoptosis. Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434'. |
| Protein Name | Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1aDual Specificity Yak1-Related KinaseHp86Protein Kinase Minibrain HomologMnbhHmnb |
| Database Links | Reactome: R-HSA-1538133 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a antibodyAnti-Dual Specificity Yak1-Related Kinase antibodyAnti-Hp86 antibodyAnti-Protein Kinase Minibrain Homolog antibodyAnti-Mnbh antibodyAnti-Hmnb antibodyAnti-DYRK1A antibodyAnti-DYRK antibodyAnti-MNB antibodyAnti-MNBH antibody |
Information sourced from Uniprot.org