| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DYNC1H1 |
| Gene ID: | 1778 |
| Uniprot ID: | DYHC1_HUMAN |
| Immunogen Region: | 1-210 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human DYNC1H1 (NP_001367.2). |
| Immunogen Sequence: | MSEPGGGGGEDGSAGLEVSA VQNVADVSVLQKHLRKLVPL LLEDGGEAPAALEAALEEKS ALEQMRKFLSDPQVHTVLVE RSTLKEDVGDEGEEEKEFIS YNINIDIHYGVKSNSLAFIK RTPVIDADKPVSSQLRVLTL SEDSPYETLHSFISNAVAPF FKSYIRESGKADRDGDKMAP SVEKKIAELEMGLLHLQQNI EIPEISLPIH |
| Function | Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity.the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression. |
| Protein Name | Cytoplasmic Dynein 1 Heavy Chain 1Cytoplasmic Dynein Heavy Chain 1Dynein Heavy Chain - Cytosolic |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2132295Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-2565942Reactome: R-HSA-3371497Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-5663220Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-68877Reactome: R-HSA-8854518Reactome: R-HSA-9609690Reactome: R-HSA-9646399Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Cytoplasmic Dynein 1 Heavy Chain 1 antibodyAnti-Cytoplasmic Dynein Heavy Chain 1 antibodyAnti-Dynein Heavy Chain - Cytosolic antibodyAnti-DYNC1H1 antibodyAnti-DHC1 antibodyAnti-DNCH1 antibodyAnti-DNCL antibodyAnti-DNECL antibodyAnti-DYHC antibodyAnti-KIAA0325 antibody |
Information sourced from Uniprot.org