| Short Description : | Rabbit monoclonal anti-Dynactin Subunit 3 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ICC/IF |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | R03-4L2 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity Purified |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | DCTN3 |
| Gene ID: | 11258 |
| Uniprot ID: | DCTN3_HUMAN |
| Immunogen: | A synthesized peptide derived from human DCTN3 |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain. |
| Function | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Together with dynein may be involved in spindle assembly and cytokinesis. |
| Protein Name | Dynactin Subunit 3Dynactin Complex Subunit 22 Kda SubunitP22 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-2565942Reactome: R-HSA-3371497Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeChromosomeCentromereKinetochoreSpindleCleavage FurrowMidbodyLocalizes To Punctate Cytoplasmic Structures And To The Centrosome During InterphaseAnd To Kinetochores And To Spindle Poles Throughout MitosisColocalizes With Dynein To The Cleavage Furrow And To Midbody Of Dividing Cells |
| Alternative Antibody Names | Anti-Dynactin Subunit 3 antibodyAnti-Dynactin Complex Subunit 22 Kda Subunit antibodyAnti-P22 antibodyAnti-DCTN3 antibodyAnti-DCTN22 antibody |
Information sourced from Uniprot.org
