| Tissue Specificity | Highly expressed in heart (at protein level). Detected in heart and soleus, a postural muscle group of the hindlimb containing the highest enrichment of slow-twitch muscle fibers. Also expressed in diaphragm, which contains some slow-twitch fibers. Not detected in the quadriceps, a fast-twitch muscle group, or in cardiac atrial muscle. Not expressed in the prenatal heart but gradually increases in abundance postnatally. |
| Function | Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Also enhances the activity of the ATP2A2/SERCA2 ATPase. Does not directly stimulate SERCA pump activity. Binds preferentially to the phosphorylated E1 and E2 conformational forms of ATP2A2 which predominate at high Ca(2+) concentrations during the systolic phase of the cardiac cycle. Competes with ATP2A2 inhibitor phospholamban (PLN) for binding to ATP2A2 and displaces PLN. Can activate ATP2A2 directly in the absence of PLN. Also enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN) and myoregulin (MRLN). |
| Protein Name | Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase Regulator DworfSerca Regulator DworfDwarf Open Reading FrameDworfSmall Transmembrane Regulator Of Ion Transport 1 |
| Cellular Localisation | Sarcoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase Regulator Dworf antibodyAnti-Serca Regulator Dworf antibodyAnti-Dwarf Open Reading Frame antibodyAnti-Dworf antibodyAnti-Small Transmembrane Regulator Of Ion Transport 1 antibodyAnti-Strit1 antibody |
Information sourced from Uniprot.org
