Anti-DUSP6 antibody (61-110) (STJ94139)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human DUSP6. AA range:61-110
General Information
| Short Description | Rabbit polyclonal anti-Dual specificity protein phosphatase 6 (61-110) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DUSP6 |
| Gene ID | 1848 |
| Uniprot ID | DUS6_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DUSP6. AA range:61-110 |
| Immunogen Region | 61-110 |
| Specificity | MKP-3 Polyclonal Antibody detects endogenous levels of MKP-3 protein. |
Additional Info
| Tissue Specificity | Expressed in keratinocytes (at protein level). |
| Post Translational Modifications | Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation. |
| Function | Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
| Protein Name | Dual Specificity Protein Phosphatase 6Dual Specificity Protein Phosphatase Pyst1Mitogen-Activated Protein Kinase Phosphatase 3Map Kinase Phosphatase 3Mkp-3 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221Reactome: R-HSA-9652817 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 6 antibodyAnti-Dual Specificity Protein Phosphatase Pyst1 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 3 antibodyAnti-Map Kinase Phosphatase 3 antibodyAnti-Mkp-3 antibodyAnti-DUSP6 antibodyAnti-MKP3 antibodyAnti-PYST1 antibody |
Information sourced from Uniprot.org