Anti-DUSP1 antibody (318-367) (STJ94136)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human MKP1. AA range:318-367
General Information
| Short Description | Rabbit polyclonal anti-Dual specificity protein phosphatase 1 (318-367) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DUSP1 |
| Gene ID | 1843 |
| Uniprot ID | DUS1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MKP1. AA range:318-367 |
| Immunogen Region | 318-367 |
| Specificity | MKP-1 Polyclonal Antibody detects endogenous levels of MKP-1 protein. |
Additional Info
| Tissue Specificity | Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. |
| Post Translational Modifications | Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. 'Lys-48'-linked polyubiquitinated by NEURL3, leading to proteasomal degradation. |
| Function | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. |
| Protein Name | Dual Specificity Protein Phosphatase 1Dual Specificity Protein Phosphatase Hvh1Mitogen-Activated Protein Kinase Phosphatase 1Map Kinase Phosphatase 1Mkp-1Protein-Tyrosine Phosphatase Cl100 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5675221 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 1 antibodyAnti-Dual Specificity Protein Phosphatase Hvh1 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 1 antibodyAnti-Map Kinase Phosphatase 1 antibodyAnti-Mkp-1 antibodyAnti-Protein-Tyrosine Phosphatase Cl100 antibodyAnti-DUSP1 antibodyAnti-CL100 antibodyAnti-MKP1 antibodyAnti-PTPN10 antibodyAnti-VH1 antibody |
Information sourced from Uniprot.org