| Post Translational Modifications | Preferentially phosphorylated in cells arrested early in S phase. Phosphorylation in the C-terminus weakens the interaction with CDC45. |
| Function | Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis.rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. |
| Protein Name | D-Aminoacyl-Trna Deacylase 1DtdDna-Unwinding Element-Binding Protein BDue-BGly-Trna(Ala DeacylaseHistidyl-Trna Synthase-Related |
| Cellular Localisation | NucleusCytoplasmAssociated With Chromatin At Some Replication Origins Containing Functional Dna-Unwinding Elements |
| Alternative Antibody Names | Anti-D-Aminoacyl-Trna Deacylase 1 antibodyAnti-Dtd antibodyAnti-Dna-Unwinding Element-Binding Protein B antibodyAnti-Due-B antibodyAnti-Gly-Trna(Ala Deacylase antibodyAnti-Histidyl-Trna Synthase-Related antibodyAnti-DTD1 antibodyAnti-C20orf88 antibodyAnti-DUEB antibodyAnti-HARS2 antibody |
Information sourced from Uniprot.org
