Anti-Draxin antibody (C-Term) (STJA0041179)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenDraxin synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of human draxin. This peptide sequence is highly conserved in rat, mouse, and chick draxin.
General Information
| Short Description | Rabbit polyclonal anti-Draxin (C-Term) for use in ELISA, WB and ICC in Chicken, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC |
| Host | Rabbit |
| Reactivity | Chicken/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:1000ICC 1:100 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Storage at-20ยฐC is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20ยฐC. |
Target Information
| Gene Symbol | DRAXIN |
| Gene ID | 374946 |
| Uniprot ID | DRAXI_HUMAN |
| Immunogen | Draxin synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of human draxin. This peptide sequence is highly conserved in rat, mouse, and chick draxin. |
| Immunogen Region | C-Term |
| Immunogen Sequence | Human |
| Specificity | The antibody detects a significant 50 kDa* protein corresponding to the molecular mass of draxin on SDS-PAGE immunoblots of rat PC12 cells, rat P1 brain, and chick E9 brain. The antibody also shows low expression of draxin in adult mouse brain. |
Additional Info
| Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. |
| Protein Name | DraxinDorsal Inhibitory Axon Guidance ProteinDorsal Repulsive Axon Guidance ProteinNeucrin |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Draxin antibodyAnti-Dorsal Inhibitory Axon Guidance Protein antibodyAnti-Dorsal Repulsive Axon Guidance Protein antibodyAnti-Neucrin antibodyAnti-DRAXIN antibodyAnti-C1orf187 antibodyAnti-PSEC0258 antibodyAnti-UNQ3119 antibodyAnti-PRO10268 antibody |
Information sourced from Uniprot.org