| Post Translational Modifications | Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58. This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions. Palmitoylated. Could be palmitoylated by DHHC3, DHHC7, DHHC15 and DHHC17. Palmitoylation occurs probably in the cysteine-rich domain and regulates DNAJC5 membrane attachment. |
| Function | Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. |
| Protein Name | Dnaj Homolog Subfamily C Member 5Ceroid-Lipofuscinosis Neuronal Protein 4Cysteine String ProteinCsp |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-888590Reactome: R-HSA-9662360 |
| Cellular Localisation | CytoplasmCytosolMembraneLipid-AnchorCytoplasmic VesicleSecretory VesicleChromaffin Granule MembraneMelanosomeCell MembraneThe Association With Membranes Is Regulated By PalmitoylationIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily C Member 5 antibodyAnti-Ceroid-Lipofuscinosis Neuronal Protein 4 antibodyAnti-Cysteine String Protein antibodyAnti-Csp antibodyAnti-DNAJC5 antibodyAnti-CLN4 antibody |
Information sourced from Uniprot.org
