Anti-DNAJB9 antibody (STJA0007185)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DNAJB9
General Information
| Short Description | Rabbit polyclonal anti-DnaJ homolog subfamily B member 9 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAJB9 |
| Gene ID | 4189 |
| Uniprot ID | DNJB9_HUMAN |
| Immunogen | Synthesized peptide derived from human DNAJB9 |
| Specificity | This antibody detects endogenous levels of DNAJB9 at Human, Mouse, Rat |
Additional Info
| Function | Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production. |
| Protein Name | Dnaj Homolog Subfamily B Member 9Endoplasmic Reticulum Dna J Domain-Containing Protein 4Er-Resident Protein Erdj4Erdj4Microvascular Endothelial Differentiation Gene 1 ProteinMdg-1 |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily B Member 9 antibodyAnti-Endoplasmic Reticulum Dna J Domain-Containing Protein 4 antibodyAnti-Er-Resident Protein Erdj4 antibodyAnti-Erdj4 antibodyAnti-Microvascular Endothelial Differentiation Gene 1 Protein antibodyAnti-Mdg-1 antibodyAnti-DNAJB9 antibodyAnti-MDG1 antibodyAnti-UNQ743 antibodyAnti-PRO1471 antibody |
Information sourced from Uniprot.org